Relational Analysis Of Anthopometric Measurements, Biochemical Parameters, Clinical Profile And Hormonal Levels Of Obese Versus Non Obese Women With Pcos In Kashmir Valley.

Abstract

BACK GROUND:-

During   the past decade, our understanding of pathophysiology of PCOS ( Polycystic Ovarian Syndrome) has undergone a remarkable Evolution. Despite our familiarity with this    disease, Polycystic ovarian Syndrome    ( PCOS)  Is considered as Multisystem Endocrinopathy. Some of it’s fundamental characteristics remain poorly recognized and understood. The   present  Study focuses on relational and Comprehensive analysis of the Anthropometric Measurements, Biochemical Parameters, Clinical Profile and Hormonal Levels of Obese versus Non      obese women with PCOS ( Polycystic ovarian syndrome) in Kashmir valley. Obesity was found to be one of the important factors that contribute to the development of long term risk of PCOS. In addition, increased obesity and abdominal adiposity  further aggravate the clinical, hormonal and metabolic parameters in PCOS and if treated, can reverse most of these abnormalities to a clinically significant degree. Our study suggeststhat anthropometric  parameters ( Especially BMI and WHR) are significantly correlated with lipid profile in PCOS patients confirming the importance of early treatment of obesity to prevent further complications in the future. We wanted to study anthropometric measurements, the    hormonal status and biochemical parameters in females       diagnosed with PCOS. Study the correlation between them and compare them with controls. The present study on 146  patients including both obese and non obese PCOS cases and 70 controls revealed that Ferriman Gallway(FG) score of the obese PCOS was more as compared to non obese and normal  controls.

Hirusitism,   acanthosisnigricans and alopecia was seen significantly raised in PCOS women in comparison to non obese PCOS and controls, giving an indication of risk of hypertension in obese women. Fasting blood glucose level and one hour (1hour) glucose level was almost same for all three groups but two hour ( 2 hour) blood glucose levels  were raised in obese    cases in comparison to the non obese PCOS and controls   Hormonal analysis of our subjects revealed that lutenizing     hormone ( LH) and ( FSH) value, values of obese PCOS , non obese PCOS and controls were almost same but testosterone levels was raised in PCOS cases but much raised in obese PCOS cases.