Pegylated Conjugates Of Microcrystalline Cellulose For Use As Tablet Super-Disintegrants: Development And Evaluation

Abstract

In the current study, superdisintegrants for fast-dissolving tablets (FDTs) have been examined using microcrystalline cellulose - polyethylene glycol conjugates. MCC was combined with polyethylene glycol (PEG) 200 and heated in the presence of a catalyst to create the PEGylated conjugate of microcrystalline cellulose (MCC). MCC-PEG conjugates were created, and the powdered conjugates were characterised using micromeritic investigations, FTIR, SEM, and powder XRD techniques. By using FT-IR, the conjugation of MCC and PEG was verified. Conjugate’s physical and chemical characteristics were contrasted with MCC. The conjugate was evaluated for water vapour uptake isotherms, maximum water saturation, water penetration rate, disintegration duration, superdisintegration power, and dissolution studies. Through direct compression, the conjugates were employed to create Lurasidone hydrochloride FDTs, and the in vitro drug release was assessed. After comparing its results with that of commercial superdisintegrants, it can be concluded that MCC–PEG conjugate can prove to be an excellent superdisintegrant