Pharmacokinetic Drug Interactions Between Clopidogrel With Aspirin

Abstract

The present study was aimed to evaluate any possible pharmacokinetic interactions between clopidogre and Asprin.  clopidogrel concomitant administration in healthy rats as a single dose  day, With the treatment was given on day one and day 8 both alone clopidogrel and Asprin concomitantly used both the drugs. The results were showed no significant difference in the t_max of clopidogrel on day 1 and day 8 respectively. These were no significant difference in both c_max and t_max of clopidogrel alone and combination of clopidogrel on day 1 and day 8 respectively. And there was no significance difference in AUC_0-t and AUC_o-inf   also in alone and combination of both drugs on day 1 and day 8^th.  Based on the results obtained from kinetic study it is evident that the single dose of Asprin with clopidogrel individually and concomitantly treated shows no statistically significant interactions in its pharmacokinetic parameters