E2-Treated U937 Cells Upregulate Il-6 Synthesis To Sequester Iron And Enhance Cell Survival And Activation

Abstract

Estrogen (E2) has been shown to play a critical role in regulating various cellular processes, including immune responses. In this study, we investigated the effects of E2 treatment on U937 cells and its impact on interleukin-6 (IL-6) synthesis, iron sequestration, cell survival, and activation. Our results demonstrate that E2-treated U937 cells upregulate IL-6 synthesis, leading to enhanced iron sequestration and improved cell survival and activation. These findings shed light on the mechanistic insights into how E2 contributes to immune regulation and provide potential therapeutic targets for manipulating immune responses.