Natural Carrier-Mediated Solubility Enhancement Of Poorly Water-Soluble Drug

Abstract

Developing efficient strategies to enhance the solubility of poorly water-soluble drugs is crucial for their successful formulation and delivery. Natural carriers offer a promising approach for this purpose, leveraging their inherent biocompatibility and the ability to modulate drug-solvent interactions through non-covalent complexation. This abstract explores the concept of utilizing natural carriers for solvent evaporation, a widely employed technique for solubility enhancement. We discuss the mechanisms by which natural carriers can improve drug solubility during solvent evaporation and the various factors influencing their efficacy. Recent advancements in natural carrier design and their integration with solvent evaporation for solubility enhancement are highlighted. The natural carrier used are zizipus spina christi gum and locust bean gum. The Rhamnaceous family, which includes the genus Ziziphus, has over 100 species of deciduous or evergreen trees and shrubs that are found worldwide in tropical and subtropical climates. Finally, the future perspectives and potential challenges associated with this approach are addressed.