Exploring Recent Progress In Oral Drug Delivery Systems.

Abstract

This thorough talk covers all the nuances of oral drug delivery systems, from the current developments in microencapsulation technology to the critical role mucus plays in gastrointestinal physiology. The discussion starts out by outlining the various roles that mucus plays in the gastrointestinal tract, such as its barrier qualities and its part in mucosal immunity. It then explores the various drug absorption mechanisms, including paracellular and transcellular pathways, as well as the difficulties caused by tight junctions. A number of oral drug delivery systems are carefully analyzed, including intestinal patches, gastrointestinal microneedles, and particulate carriers like liposomes and micelles. The discussion goes on to discuss the potential for improved therapeutic efficacy of sustained drug delivery strategies, such as thiol-functionalized carriers and mucoadhesive hydrogels. Novelties in gastric-resident structures, like foldable rings with elastic properties and solvent-free microencapsulation technologies utilizing microfluidic devices, are emphasized as potentially effective approaches to surmount current drug delivery obstacles. The dynamic nature of oral drug delivery research and its potential to transform therapeutic interventions are highlighted in this thorough discussion.