Preparation And Characterization Nanoparticles To Improve Solubility Of Hydrophobic Drug

Abstract

The challenge of poor solubility is a significant hurdle in the development of hydrophobic drugs, impacting their bioavailability and therapeutic efficacy. According to the Biopharmaceutical Classification System (BCS), approximately 40% of new chemical entities are classified as Class II drugs, which are characterized by low solubility and high permeability ^[1]. These solubility issues can lead to incomplete drug absorption, necessitating innovative formulation strategies to enhance the bioavailability of such compounds.