Invivo Analgesic and Anti-Inflammatory Characterization of Transdermal Patch Containing Essential Oils
Keywords:
Transdermal patch, Essential oils, Capsaicin, Anti-inflammatory, Analgesic, Carrageenan-induced paw edema, Tail flick test.Abstract
This study evaluates the in vivo anti-inflammatory and analgesic potential of transdermal patches formulated with herbal essential oils—Capsaicin, Methyl Salicylate, Menthol, and Thymol—using optimized polymeric matrices. Transdermal patches were prepared using HPMC K100, HPMC K15, and PEG as the base and tested using carrageenan-induced rat paw edema and tail flick tests. Patches demonstrated significant anti-inflammatory activity by reducing paw swelling and exhibited notable analgesic effects. The findings confirm the suitability of essential oil-based transdermal patches as promising alternatives for pain and inflammation management with improved patient compliance and sustained drug release.
